Selected Publications
James S. Choi, Ana C. Ayupe, Felipe Beckedorff, Robyn McCartan, Paola Catanuto, Konstantin Levay, Kevin K. Park, Single-Nucleus RNA Sequencing of Developing Superior Colliculus Identifies Neuronal Diversity and Candidate Mediators of Circuit Assembly. Cell Reports (in press)
Mary L. Tapia and Kevin K. Park. Awakening dormant neurons long after spinal cord injury. PLoS Biology, e3001830. PMID: 36174052 (2022)
Mary L. Tapia, Gabriel Nascimento Dos Santos, Kevin K. Park. Subtype-specific survival and regeneration of retinal ganglion cells in response to injury. Front Cell Dev Biol, doi: 10.3389 (2022)
Marcio Ribeiro, Ana C Ayupe, Felipe C Beckedorff, Konstantin Levay, Sara Rodriguez, Pantelis Tsoulfas, Jae K Lee, Gabriel Nascimento-Dos-Santos, Kevin K Park. Retinal ganglion cell expression of cytokine enhances occupancy of NG2 cell-derived astrocytes at the nerve injury site: Implication for axon regeneration. Experimental Neurology, Volume 355, 114147 (2022)
Ana C. Ayupe, Felipe Beckedorff, Konstantin Levay, Benito Yon, Yadira Salgueiro, Ramin Shiekhattar, Kevin K. Park. Identification of Long Noncoding RNAs in Injury-Resilient and Injury-Susceptible Mouse Retinal Ganglion Cells. BMC Genomics, 22(1):741 (2021)
Eric R. Bray, Benjamin J. Yungher, Konstantin Levay, Marcio Ribeiro, Gennady Dvoryanchikov, Ana C. Ayupe, Kinjal Thakor, Victoria Marks, Michael Randolph, Matt C. Danzi, Tiffany Schmidt, Nirupa Chaudhari, Vance P. Lemmon, Samer Hattar, Kevin K. Park. Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells. Neuron, Volume 103, Pages 642-65 (2019)
Xueting Luo, Marcio Ribeiro, Eric R. Bray, Do-Hun Lee, Benjamin J. Yungher, Saloni T. Mehta, Kinjal A. Thakor, Francisca Diaz, Jae K. Lee, Carlos T. Moraes, John L. Bixby, Vance P. Lemmon, Kevin K. Park. Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in Adult Central Nervous System. Cell Reports, 12;15(2):398-410 (2016)
Hu, Y*., Park, K.K*., Yang, L*., Wei X*., Yang, Q., Thielen, P., Lee, A.H., Cartoni, R., Glimcher, L.H., Chen D.F., He, Z.,. Differential Effects of Unfolded Protein Response Pathways on Axon Injury-induced Death of Retinal Ganglion Cells. Neuron, 9;73(3):445-52 (2012)
Bray, E.R., Noga. M., Thakor, K., Wang, Y.F., Lemmon, V.P., Park, K.K*., Tsoulfas, P*. 3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths. eNeuro, 4(4) (2017) (*, corresponding author)
Sun, F., Park, K.K., Belin, S., Wang, D., Lu, T., Chen, G., Yeung, C., Feng, G., Yankner, B.A., He, Z., Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature, 480(7377):372-375 (2011)
Luo, X,, Salgueiro, Y., Beckerman, S.R., Lemmon, V.P., Tsoulfas, P., Park, K.K., Three-dimensional evaluation of retinal ganglion cell axon regeneration and path-finding in whole mouse tissue after injury. Experimental Neurology, 247:653-62 (2013) (Cover Image)
Smith, P.D., Sun, F., Park, K.K., Cai, B., Wang, C., Kuwako, K., Carrasco, I., Connolly, L., He, Z., SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron, 64: 617-623 (2009)
Park, K.K.,*, Liu, K*., Hu, Y*., Smith, P.D*., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., He, Z., Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science, 322: 963-66 (2008)
Additional Publications
Ling-Ping Cen, Kevin K. Park, Kowk-Fai So. Clin. Exp. Ophthalmol. Optic nerve diseases and regeneration: How far are we from the promised land? In Press (2023)
Sarah Sonny, Huijun Yuan, Shaoyi Chen, Matthew R. Duncan, Pingping Chen, Merline Benny, Karen Young, Kevin K. Park, Augusto F. Schmidt & Shu Wu. GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice. Scientific Reports 143 (2023)
Sean D Meehan, Leila Abdelrahman, Jennifer Arcuri, Kevin K Park, Mohammad Samarah, Sanjoy K Bhattacharya. Proteomics and systems biology in optic nerve regeneration. Adv Protein Chem Struct Biol 127:249-270 (2021)
Márcio Ribeiro, Konstanin Levay, Benito Yon, Ana Ayupe, Yadira Salgueiro, Kevin K. Park. Neural Cadherin Plays Distinct Roles for Neuronal Survival and Axon Growth under Different Regenerative Conditions. eNeuro 0325-20.(2020)
Kevin K. Park. Regeneration of Retinal Ganglion Cell Axons. The Senses: A Comprehensive Reference, 2nd edition, Volume 1, Chapter 1.38; 630-641 (2020)
C. Moses, S. I. Hodgetts, F. Nugent, G. Ben-Ary, K. K. Park, P. Blancafort & A. R. Harvey. Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. Scientifc Reports 10, 11393 (2020)
Muhammad Zain Chauhan, Jennifer Arcuri, Kevin K. Park, Maroof Khan Zafar, Rabeet Fatmi, Abigail S. Hackam, Yuqin Yin, Larry Benowitz, Jeffrey L. Goldberg, Mohammad Samarah, Sanjoy K. Bhattacharya. Multi-omic analyses of growth cones at different developmental stages provides insight into pathways in adult neuro-regeneration. iScience, 23, Issue 2, 100836 (2020)
Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK. Optic nerve regeneration in mammals: Regenerated or spared axons? Experimental Neurology, 14;296:83-88 (2017)
Yungher, B.J., Ribeiro, M., Park, K.K. Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice. Invest. Ophthalmol. Vis. Sci. 1;58(3):1743-1750 (2017)
Patel, A.K., Park, K.K., Hackam, A.S., Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse. Neuroscience 343:372-383 (2017)
Park KK, Luo X, Mooney SJ, Yungher BJ, Belin S, Wang C, Holmes MM, He Z.Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats. J Comp Neurol. 1;525(2):380-388 (2017)
Dvoriantchikova G, Pappas S, Luo X, Ribeiro M, Danek D, Pelaez D, Park KK, Ivanov D. Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells. Eur J Neurosci. 44(11):2935-2943 (2016)
Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP. Hyperactivated Stat3 boosts axon regeneration in the CNS. Experimental Neurology, 280:115-20 (2016)
Yungher BJ, Luo X, Salgueiro Y, Blackmore MG, Park KK. Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target. Gene Therapy, 22(10):811-21, 2015
Lee DH, Luo X, Yungher BJ, Bray E, Lee JK, Park KK. Mammalian Target of Rapamycin's Distinct Roles and Effectiveness in Promoting Compensatory Axonal Sprouting in the Injured CNS. J. Neurosci. 34(46):15347-55 (2014)
Soderblom C, Lee DH, Dawood A, Carballosa M, Jimena Santamaria A, Benavides FD, Jergova S, Grumbles RM, Thomas CK, Park KK, Guest JD, Lemmon VP, Lee JK, Tsoulfas P3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates. eNeuro 2(2) (2015)
Soderblom C, Luo X, Blumenthal E, Bray E, Lyapichev K, Ramos J, Krishnan V, Lai-Hsu C, Park KK, Tsoulfas P, Lee JK. Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury. J. Neurosci. 33(34):13882-7 (2013)
Xueting Luo, Ben Yungher, Kevin K. Park. Application of Tissue Clearing and Light Sheet Fluorescence Microscopy to Assess Optic Nerve Regeneration in Unsectioned Tissues (2014) Methods in Molecular Biology, Volume 1162, 2014, pp 209-217.
Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H. Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration. Experimental Neurology 248C:157-169 (2013)
Chou, T.H., Park, K.K., Luo, X., Porciatti, V., Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells. Invest. Ophthalmol. Vis. Sci., 54:1236-43 (2013)
Luo, X., Park, K.K., Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3. Int. Rev. Neurobiol., 105:141-73 (2012)
Liu, K., Tedeschi, A., Park, K.K., He, Z., Neuronal intrinsic mechanisms of axon regeneration. Annual Rev. Neurosci., 34:131-52 (2011)
Dallimore, E.J., Park, K.K., Pollett, M.A., Taylor, J.S., Harvey,A.R., The life, death and regenerative ability of immature and mature rat retinal ganglion cells is influenced by their birthdate. Experimental Neurology, 225: 353-65 (2010)
Liu, K., Lu, Y., Lee, J.K., Samara, R., Willenberg, R., Kraxberger, I., Tedeschi, A., Park, K.K., Jin, D., Cai, B., Xu, B., Connolly, L., Steward, O., Zheng B., He, Z., PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neuroscience, 13: 1075-81 (2010) (Issue Cover)
Park, K.K+., Liu, K., Hu, Y., Kanter, J.L., He, Z., PTEN/mTOR and axon regeneration. Experimental Neurology, 223: 45-50 (2010)
Kevin K. Park, Ying Hu, Jill Muhling, Margarette A. Pollett, Elizabeth J. Dallimore, Ann M. Turnley, Qi Cui and Alan R. Harvey. Cytokine-induced SOCS expression is inhibited by cAMP analogue: Impact on regeneration in injured retina. Mol. Cell. Neuroscience, 41(3):313-24. (2009)
Harvey, A.R, Hu, Y., Leaver, S.G., Mellough, C.B., Park, K.K., Verhaagen, J., Plant, G.W., Cui, Q., Gene Therapy and Transplantation in CNS Repair: The Visual System. Prog Ret Eye Res., 25: 449-89 (2006)
Park, K, Luo, J., Hisheh, S., Harvey, A.R., Cui, Q., Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J. Neurosci., 2448: 10806-15 (2004)
James S. Choi, Ana C. Ayupe, Felipe Beckedorff, Robyn McCartan, Paola Catanuto, Konstantin Levay, Kevin K. Park, Single-Nucleus RNA Sequencing of Developing Superior Colliculus Identifies Neuronal Diversity and Candidate Mediators of Circuit Assembly. Cell Reports (in press)
Mary L. Tapia and Kevin K. Park. Awakening dormant neurons long after spinal cord injury. PLoS Biology, e3001830. PMID: 36174052 (2022)
Mary L. Tapia, Gabriel Nascimento Dos Santos, Kevin K. Park. Subtype-specific survival and regeneration of retinal ganglion cells in response to injury. Front Cell Dev Biol, doi: 10.3389 (2022)
Marcio Ribeiro, Ana C Ayupe, Felipe C Beckedorff, Konstantin Levay, Sara Rodriguez, Pantelis Tsoulfas, Jae K Lee, Gabriel Nascimento-Dos-Santos, Kevin K Park. Retinal ganglion cell expression of cytokine enhances occupancy of NG2 cell-derived astrocytes at the nerve injury site: Implication for axon regeneration. Experimental Neurology, Volume 355, 114147 (2022)
Ana C. Ayupe, Felipe Beckedorff, Konstantin Levay, Benito Yon, Yadira Salgueiro, Ramin Shiekhattar, Kevin K. Park. Identification of Long Noncoding RNAs in Injury-Resilient and Injury-Susceptible Mouse Retinal Ganglion Cells. BMC Genomics, 22(1):741 (2021)
Eric R. Bray, Benjamin J. Yungher, Konstantin Levay, Marcio Ribeiro, Gennady Dvoryanchikov, Ana C. Ayupe, Kinjal Thakor, Victoria Marks, Michael Randolph, Matt C. Danzi, Tiffany Schmidt, Nirupa Chaudhari, Vance P. Lemmon, Samer Hattar, Kevin K. Park. Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells. Neuron, Volume 103, Pages 642-65 (2019)
Xueting Luo, Marcio Ribeiro, Eric R. Bray, Do-Hun Lee, Benjamin J. Yungher, Saloni T. Mehta, Kinjal A. Thakor, Francisca Diaz, Jae K. Lee, Carlos T. Moraes, John L. Bixby, Vance P. Lemmon, Kevin K. Park. Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in Adult Central Nervous System. Cell Reports, 12;15(2):398-410 (2016)
Hu, Y*., Park, K.K*., Yang, L*., Wei X*., Yang, Q., Thielen, P., Lee, A.H., Cartoni, R., Glimcher, L.H., Chen D.F., He, Z.,. Differential Effects of Unfolded Protein Response Pathways on Axon Injury-induced Death of Retinal Ganglion Cells. Neuron, 9;73(3):445-52 (2012)
Bray, E.R., Noga. M., Thakor, K., Wang, Y.F., Lemmon, V.P., Park, K.K*., Tsoulfas, P*. 3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths. eNeuro, 4(4) (2017) (*, corresponding author)
Sun, F., Park, K.K., Belin, S., Wang, D., Lu, T., Chen, G., Yeung, C., Feng, G., Yankner, B.A., He, Z., Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature, 480(7377):372-375 (2011)
Luo, X,, Salgueiro, Y., Beckerman, S.R., Lemmon, V.P., Tsoulfas, P., Park, K.K., Three-dimensional evaluation of retinal ganglion cell axon regeneration and path-finding in whole mouse tissue after injury. Experimental Neurology, 247:653-62 (2013) (Cover Image)
Smith, P.D., Sun, F., Park, K.K., Cai, B., Wang, C., Kuwako, K., Carrasco, I., Connolly, L., He, Z., SOCS3 deletion promotes optic nerve regeneration in vivo. Neuron, 64: 617-623 (2009)
Park, K.K.,*, Liu, K*., Hu, Y*., Smith, P.D*., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., He, Z., Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science, 322: 963-66 (2008)
Additional Publications
Ling-Ping Cen, Kevin K. Park, Kowk-Fai So. Clin. Exp. Ophthalmol. Optic nerve diseases and regeneration: How far are we from the promised land? In Press (2023)
Sarah Sonny, Huijun Yuan, Shaoyi Chen, Matthew R. Duncan, Pingping Chen, Merline Benny, Karen Young, Kevin K. Park, Augusto F. Schmidt & Shu Wu. GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice. Scientific Reports 143 (2023)
Sean D Meehan, Leila Abdelrahman, Jennifer Arcuri, Kevin K Park, Mohammad Samarah, Sanjoy K Bhattacharya. Proteomics and systems biology in optic nerve regeneration. Adv Protein Chem Struct Biol 127:249-270 (2021)
Márcio Ribeiro, Konstanin Levay, Benito Yon, Ana Ayupe, Yadira Salgueiro, Kevin K. Park. Neural Cadherin Plays Distinct Roles for Neuronal Survival and Axon Growth under Different Regenerative Conditions. eNeuro 0325-20.(2020)
Kevin K. Park. Regeneration of Retinal Ganglion Cell Axons. The Senses: A Comprehensive Reference, 2nd edition, Volume 1, Chapter 1.38; 630-641 (2020)
C. Moses, S. I. Hodgetts, F. Nugent, G. Ben-Ary, K. K. Park, P. Blancafort & A. R. Harvey. Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. Scientifc Reports 10, 11393 (2020)
Muhammad Zain Chauhan, Jennifer Arcuri, Kevin K. Park, Maroof Khan Zafar, Rabeet Fatmi, Abigail S. Hackam, Yuqin Yin, Larry Benowitz, Jeffrey L. Goldberg, Mohammad Samarah, Sanjoy K. Bhattacharya. Multi-omic analyses of growth cones at different developmental stages provides insight into pathways in adult neuro-regeneration. iScience, 23, Issue 2, 100836 (2020)
Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK. Optic nerve regeneration in mammals: Regenerated or spared axons? Experimental Neurology, 14;296:83-88 (2017)
Yungher, B.J., Ribeiro, M., Park, K.K. Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice. Invest. Ophthalmol. Vis. Sci. 1;58(3):1743-1750 (2017)
Patel, A.K., Park, K.K., Hackam, A.S., Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse. Neuroscience 343:372-383 (2017)
Park KK, Luo X, Mooney SJ, Yungher BJ, Belin S, Wang C, Holmes MM, He Z.Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats. J Comp Neurol. 1;525(2):380-388 (2017)
Dvoriantchikova G, Pappas S, Luo X, Ribeiro M, Danek D, Pelaez D, Park KK, Ivanov D. Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells. Eur J Neurosci. 44(11):2935-2943 (2016)
Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP. Hyperactivated Stat3 boosts axon regeneration in the CNS. Experimental Neurology, 280:115-20 (2016)
Yungher BJ, Luo X, Salgueiro Y, Blackmore MG, Park KK. Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target. Gene Therapy, 22(10):811-21, 2015
Lee DH, Luo X, Yungher BJ, Bray E, Lee JK, Park KK. Mammalian Target of Rapamycin's Distinct Roles and Effectiveness in Promoting Compensatory Axonal Sprouting in the Injured CNS. J. Neurosci. 34(46):15347-55 (2014)
Soderblom C, Lee DH, Dawood A, Carballosa M, Jimena Santamaria A, Benavides FD, Jergova S, Grumbles RM, Thomas CK, Park KK, Guest JD, Lemmon VP, Lee JK, Tsoulfas P3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates. eNeuro 2(2) (2015)
Soderblom C, Luo X, Blumenthal E, Bray E, Lyapichev K, Ramos J, Krishnan V, Lai-Hsu C, Park KK, Tsoulfas P, Lee JK. Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury. J. Neurosci. 33(34):13882-7 (2013)
Xueting Luo, Ben Yungher, Kevin K. Park. Application of Tissue Clearing and Light Sheet Fluorescence Microscopy to Assess Optic Nerve Regeneration in Unsectioned Tissues (2014) Methods in Molecular Biology, Volume 1162, 2014, pp 209-217.
Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H. Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration. Experimental Neurology 248C:157-169 (2013)
Chou, T.H., Park, K.K., Luo, X., Porciatti, V., Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells. Invest. Ophthalmol. Vis. Sci., 54:1236-43 (2013)
Luo, X., Park, K.K., Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3. Int. Rev. Neurobiol., 105:141-73 (2012)
Liu, K., Tedeschi, A., Park, K.K., He, Z., Neuronal intrinsic mechanisms of axon regeneration. Annual Rev. Neurosci., 34:131-52 (2011)
Dallimore, E.J., Park, K.K., Pollett, M.A., Taylor, J.S., Harvey,A.R., The life, death and regenerative ability of immature and mature rat retinal ganglion cells is influenced by their birthdate. Experimental Neurology, 225: 353-65 (2010)
Liu, K., Lu, Y., Lee, J.K., Samara, R., Willenberg, R., Kraxberger, I., Tedeschi, A., Park, K.K., Jin, D., Cai, B., Xu, B., Connolly, L., Steward, O., Zheng B., He, Z., PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neuroscience, 13: 1075-81 (2010) (Issue Cover)
Park, K.K+., Liu, K., Hu, Y., Kanter, J.L., He, Z., PTEN/mTOR and axon regeneration. Experimental Neurology, 223: 45-50 (2010)
Kevin K. Park, Ying Hu, Jill Muhling, Margarette A. Pollett, Elizabeth J. Dallimore, Ann M. Turnley, Qi Cui and Alan R. Harvey. Cytokine-induced SOCS expression is inhibited by cAMP analogue: Impact on regeneration in injured retina. Mol. Cell. Neuroscience, 41(3):313-24. (2009)
Harvey, A.R, Hu, Y., Leaver, S.G., Mellough, C.B., Park, K.K., Verhaagen, J., Plant, G.W., Cui, Q., Gene Therapy and Transplantation in CNS Repair: The Visual System. Prog Ret Eye Res., 25: 449-89 (2006)
Park, K, Luo, J., Hisheh, S., Harvey, A.R., Cui, Q., Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J. Neurosci., 2448: 10806-15 (2004)
